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The dangerous new synthetic drug α‐PVP as the hydrated chloride salt α‐pyrrolidinopentiophenone hydrochloride 0.786‐hydrate
Author(s) -
Wood Matthew R.,
Bernal Ivan,
Lalancette Roger A.
Publication year - 2016
Publication title -
acta crystallographica section c
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 17
ISSN - 2053-2296
DOI - 10.1107/s2053229615023621
Subject(s) - salt (chemistry) , hydrate , hydrochloride , drug , chemistry , chloride , pharmacology , organic chemistry , medicine
α‐Pyrrolidinovalerophenone (α‐PVP), a dangerous designer drug, is now being marketed around the world as a harmless `bath salt', when in reality it is a powerful β‐ketone phenethylamine stimulant. A sample of the free base from a recent law‐enforcement seizure was crystallized as the HCl salt [systematic name: 1‐(1‐oxo‐1‐phenylpentan‐2‐yl)pyrrolidin‐1‐ium chloride 0.786‐hydrate], C 15 H 22 NO + ·Cl − ·0.786H 2 O. In the crystal structure, the propyl chain is nearly perpendicular to both the phenyl ring and the carbonyl group. The hydrogen‐bonding scheme involves the quaternary N atom, the Cl − anion and the partially occupied (0.786) water molecule, forming centrosymmetric dimers.