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C 60 in a peptidic cage: a case of symmetry mismatch studied by crystallography and solid‐state NMR
Author(s) -
Gilski Miroslaw,
Bernatowicz Piotr,
Sakowicz Arkadiusz,
Szymański Marek P.,
Zalewska Aldona,
Szumna Agnieszka,
Jaskólski Mariusz
Publication year - 2020
Publication title -
acta crystallographica section b
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.604
H-Index - 33
ISSN - 2052-5206
DOI - 10.1107/s2052520620009944
Subject(s) - crystallography , differential scanning calorimetry , molecule , fullerene , chemistry , rotational diffusion , supramolecular chemistry , crystallographic point group , molecular symmetry , nuclear magnetic resonance spectroscopy , anisotropy , electron paramagnetic resonance , chemical physics , crystal structure , materials science , nuclear magnetic resonance , stereochemistry , thermodynamics , quantum mechanics , physics , organic chemistry
A supramolecular complex, formed by encapsulation of C 60 fullerene in a molecular container built from two resorcin[4]arene rims zipped together by peptidic arms hydrogen bonded into a cylindrical β‐sheet, was studied by X‐ray crystallography, solid‐state and solution NMR, EPR spectroscopy and differential scanning calorimetry (DSC). The crystal structure, determined at 100 K, reveals that the complex occupies 422 site symmetry, which is compatible with the molecular symmetry of the container but not of the fullerene molecule, which has only 222 symmetry. The additional crystallographic symmetry leads to a complicated but discrete disorder, which could be resolved and modelled using advanced features of the existing refinement software. Solid‐state NMR measurements at 184–333 K indicate that the thermal motion of C 60 in this temperature range is fast but has different activation energies at different temperatures, which was attributed to a phase transition, which was confirmed by DSC. Intriguingly, the activation energy for reorientations of C 60 in the solid state is very similar for the free and encaged molecules. Also, the rotational diffusion coefficients seem to be very similar or even slightly higher for the encaged fullerene compared to the free molecule. We also found that chemical shift anisotropy (CSA) is not the main relaxation mechanism for the 13 C spins of C 60 in the studied complex.