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Relationships between hydrogen bonds and halogen bonds in biological systems
Author(s) -
Rowe Rhia K.,
Ho P. Shing
Publication year - 2017
Publication title -
acta crystallographica section b
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.604
H-Index - 33
ISSN - 2052-5206
DOI - 10.1107/s2052520617003109
Subject(s) - biomolecule , halogen bond , hydrogen bond , rational design , function (biology) , molecular recognition , halogen , combinatorial chemistry , chemistry , nucleic acid , computational biology , molecule , nanotechnology , computer science , materials science , biology , biochemistry , organic chemistry , evolutionary biology , alkyl
The recent recognition that halogen bonding (XB) plays important roles in the recognition and assembly of biological molecules has led to new approaches in medicinal chemistry and biomolecular engineering. When designing XBs into strategies for rational drug design or into a biomolecule to affect its structure and function, we must consider the relationship between this interaction and the more ubiquitous hydrogen bond (HB). In this review, we explore these relationships by asking whether and how XBs can replace, compete against or behave independently of HBs in various biological systems. The complex relationships between the two interactions inform us of the challenges we face in fully utilizing XBs to control the affinity and recognition of inhibitors against their therapeutic targets, and to control the structure and function of proteins, nucleic acids and other biomolecular scaffolds.