Open AccessSynchrotron radiation micro‐tomography for high‐resolution neurovascular network morphology investigation
Author(s) -
Cao Yong,
Zhang Mengqi,
Ding Hui,
Chen Zhuohui,
Tang Bin,
Wu Tianding,
Xiao Bo,
Duan Chunyue,
Ni Shuangfei,
Jiang Liyuan,
Luo Zixiang,
Li Chengjun,
Zhao Jinyun,
Liao Shenghui,
Yin Xianzhen,
Fu Yalan,
Xiao Tiqiao,
Lu Hongbin,
Hu Jianzhong
Publication year - 2019
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s1600577519003060
Subject(s) - neurovascular bundle , synchrotron radiation , tomography , synchrotron , neuroimaging , biomedical engineering , radiology , neuroscience , medicine , optics , physics , anatomy , biology
There has been increasing interest in using high‐resolution micro‐tomography to investigate the morphology of neurovascular networks in the central nervous system, which remain difficult to characterize due to their microscopic size as well as their delicate and complex 3D structure. Synchrotron radiation X‐ray imaging, which has emerged as a cutting‐edge imaging technology with a high spatial resolution, provides a novel platform for the non‐destructive imaging of microvasculature networks at a sub‐micrometre scale. When coupled with computed tomography, this technique allows the characterization of the 3D morphology of vasculature. The current review focuses on recent progress in developing synchrotron radiation methodology and its application in probing neurovascular networks, especially the pathological changes associated with vascular abnormalities in various model systems. Furthermore, this tool represents a powerful imaging modality that improves our understanding of the complex biological interactions between vascular function and neuronal activity in both physiological and pathological states.