Open AccessAdvantages of breast cancer visualization and characterization using synchrotron radiation phase‐contrast tomography
Author(s) -
Pacilè Serena,
Baran Patrycja,
Dullin Christian,
Dimmock Matthew,
Lockie Darren,
Missbach-Guntner Jeannine,
Quiney Harry,
McCormack Mikkaela,
Mayo Sheridan,
Thompson Darren,
Nesterets Yakov,
Hall Chris,
Pavlov Konstantin,
Prodanovic Zdenka,
Tonutti Maura,
Accardo Agostino,
Fox Jane,
Tavakoli Taba Seyedamir,
Lewis Sarah,
Brennan Patrick,
Hausermann Daniel,
Tromba Giuliana,
Gureyev Tim
Publication year - 2018
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s1600577518010172
Subject(s) - synchrotron radiation , breast cancer , medicine , beamline , medical physics , mammography , radiology , radiological weapon , synchrotron , tomography , nuclear medicine , medical imaging , cancer , optics , physics , beam (structure)
The aim of this study was to highlight the advantages that propagation‐based phase‐contrast computed tomography (PB‐CT) with synchrotron radiation can provide in breast cancer diagnostics. For the first time, a fresh and intact mastectomy sample from a 60 year old patient was scanned on the IMBL beamline at the Australian Synchrotron in PB‐CT mode and reconstructed. The clinical picture was described and characterized by an experienced breast radiologist, who underlined the advantages of providing diagnosis on a PB‐CT volume rather than conventional two‐dimensional modalities. Subsequently, the image quality was assessed by 11 breast radiologists and medical imaging experts using a radiological scoring system. The results indicate that, with the radiation dose delivered to the sample being equal, the accuracy of a diagnosis made on PB‐CT images is significantly higher than one using conventional techniques.