Open AccessQuantitative study of the influence of swimming therapy on osteoporosis rat models based on synchrotron radiation computed tomogaphy
Author(s) -
Huang Liya,
Xu Jun,
Guo Han,
Wang Yujie,
Zhao Jun,
Sun Jianqi
Publication year - 2018
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s160057751800276x
Subject(s) - osteoporosis , medicine , radiation therapy , bone structure , lumbar , quantitative computed tomography , lumbar vertebrae , bone disease , radiology , bone density , nuclear medicine , biomedical engineering
Osteoporosis is a bone disease with a variety of causes, leading to bone pain and fragility to fracture. Major treatment methods include nutrition therapy, exercise therapy, drug therapy and surgical treatment, among which exercise therapy, such as swimming, is the most effective. To investigate the optimal swimming therapy regime for postmenopausal women, the effects of eight weeks of different intensity swimming exercises were studied in rat models. After the swimming program, lumbar vertebrae were dissected from all the rats and scanned by synchrotron radiation computed tomography (SRCT). Histomorphometry analysis and finite‐element analysis were carried out on the trabecular structure of the L4 lumbar based on the acquired SRCT slices. Histomorphometry analysis showed that swimming can alleviate the decrease in bone strength induced by estrogen deficiency, and moderate‐intensity swimming was found to have the most significant effect.