Open AccessMÖNCH detector enables fast and low‐dose free‐propagation phase‐contrast computed tomography of in situ mouse lungs
Author(s) -
Dullin Christian,
Albers Jonas,
Tromba Giuliana,
Andrä Marie,
Ramilli Marco,
Bergamaschi Anna
Publication year - 2018
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s160057751701668x
Subject(s) - in vivo , phase contrast microscopy , lung , computed tomography , detector , lung disease , tomography , breathing , nuclear medicine , biomedical engineering , medicine , biology , radiology , physics , optics , microbiology and biotechnology , anatomy
Due to the complexity of the underlying pathomechanism, in vivo mouse lung‐disease models continue to be of great importance in preclinical respiratory research. Longitudinal studies following the cause of a disease or evaluating treatment efficacy are of particular interest but challenging due to the small size of the mouse lung and the fast breathing rate. Synchrotron‐based in‐line phase‐contrast computed tomography imaging has been successfully applied in lung research in various applications, but mostly at dose levels that forbid longitudinal in vivo studies. Here, the novel charge‐integrating hybrid detector MÖNCH is presented, which enables imaging of mouse lungs at a pixel size of 25 µm, in less than 10 s and with an entrance dose of about 70 mGy, which therefore will allow longitudinal lung disease studies to be performed in mouse models.