Open AccessStudying solutions at high shear rates: a dedicated microfluidics setup
Author(s) -
Wieland D. C. F.,
Garamus V. M.,
Zander T.,
Krywka C.,
Wang M.,
Dedinaite A.,
Claesson P. M.,
Willumeit-Römer R.
Publication year - 2016
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s1600577515024856
Subject(s) - microfluidics , shear (geology) , shear rate , scattering , small angle x ray scattering , mechanics , lysozyme , materials science , optics , chemistry , physics , nanotechnology , composite material , rheology , biochemistry
The development of a dedicated small‐angle X‐ray scattering setup for the investigation of complex fluids at different controlled shear conditions is reported. The setup utilizes a microfluidics chip with a narrowing channel. As a consequence, a shear gradient is generated within the channel and the effect of shear rate on structure and interactions is mapped spatially. In a first experiment small‐angle X‐ray scattering is utilized to investigate highly concentrated protein solutions up to a shear rate of 3 s −1 . These data demonstrate that equilibrium clusters of lysozyme are destabilized at high shear rates.