Open AccessIn vivo pink‐beam imaging and fast alignment procedure for rat brain tumor radiation therapy
Author(s) -
Nemoz Christian,
Kibleur Astrid,
Hyacinthe Jean Noël,
Berruyer Gilles,
Brochard Thierry,
BräuerKrisch Elke,
Le Duc Géraldine,
Brun Emmanuel,
Elleaume Hélène,
Serduc Raphaël
Publication year - 2016
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s1600577515018561
Subject(s) - microbeam , wiggler , radiation therapy , nuclear medicine , irradiation , synchrotron radiation , optics , x ray , beam (structure) , materials science , in vivo , synchrotron , radiation , medical physics , biomedical engineering , medicine , physics , radiology , nuclear physics , biology , microbiology and biotechnology , cathode ray , electron
A fast positioning method for brain tumor microbeam irradiations for preclinical studies at third‐generation X‐ray sources is described. The three‐dimensional alignment of the animals relative to the X‐ray beam was based on the X‐ray tomography multi‐slices after iodine infusion. This method used pink‐beam imaging produced by the ID17 wiggler. A graphical user interface has been developed in order to define the irradiation parameters: field width, height, number of angles and X‐ray dose. This study is the first reporting an image guided method for soft tissue synchrotron radiotherapy. It allowed microbeam radiation therapy irradiation fields to be reduced by a factor of ∼20 compared with previous studies. It permitted more targeted, more efficient brain tumor microbeam treatments and reduces normal brain toxicity of the radiation treatment.