Open AccessDetermination of nanostructure of liposomes containing two model drugs by X‐ray scattering from a synchrotron source
Author(s) -
Nasedkin Alexandr,
Davidsson Jan,
KumpugdeeVollrath Mont
Publication year - 2013
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s0909049513020074
Subject(s) - bilayer , liposome , nanostructure , scattering , small angle x ray scattering , synchrotron , materials science , lipid bilayer , x ray , chemistry , nanotechnology , membrane , chemical physics , crystallography , optics , physics , biochemistry
Small‐angle X‐ray scattering has been employed to study how the introduction of paracetamol and acetylsalicylic acid into a liposome bilayer system affects the system's nanostructure. An X‐ray scattering model, developed for multilamellar liposome systems [Pabst et al. (2000), Phys. Rev. E , 62 , 4000–4009], has been used to fit the experimental data and to extract information on how structural parameters, such as the number and thickness of the bilayers of the liposomes, thickness of the water layer in between the bilayers, size and volume of the head and tail groups, are affected by the drugs and their concentration. Even though the experimental data reveal a complicated picture of the drug–bilayer interaction, they clearly show a correlation between nanostructure, drug and concentration in some aspects. The localization of the drugs in the bilayers is discussed.