Open AccessSynchrotron X‐ray fluorescence studies of a bromine‐labelled cyclic RGD peptide interacting with individual tumor cells
Author(s) -
Sheridan Erin J.,
Austin Christopher J. D.,
Aitken Jade B.,
Vogt Stefan,
Jolliffe Katrina A.,
Harris Hugh H.,
Rendina Louis M.
Publication year - 2013
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s0909049513001647
Subject(s) - peptide , synchrotron , biodistribution , fluorescence , bromine , chemistry , x ray , cyclic peptide , x ray fluorescence , biophysics , radiochemistry , biochemistry , in vitro , optics , physics , biology , organic chemistry
The first example of synchrotron X‐ray fluorescence imaging of cultured mammalian cells in cyclic peptide research is reported. The study reports the first quantitative analysis of the incorporation of a bromine‐labelled cyclic RGD peptide and its effects on the biodistribution of endogenous elements (for example, K and Cl) within individual tumor cells.