Open AccessIncrease of lifespan for glioma‐bearing rats by using minibeam radiation therapy
Author(s) -
Prezado Yolanda,
Sarun Sukhena,
Gil Silvia,
Deman Pierre,
Bouchet Audrey,
Le Duc Geraldine
Publication year - 2012
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s0909049511047042
Subject(s) - gliosarcoma , irradiation , radiation therapy , synchrotron radiation , glioma , materials science , nuclear medicine , interlacing , radiation , optics , cancer research , biomedical engineering , medicine , physics , radiology , computer science , nuclear physics , operating system
This feasibility work assesses the therapeutic effectiveness of minibeam radiation therapy, a new synchrotron radiotherapy technique. In this new approach the irradiation is performed on 9L gliosarcoma‐bearing rats with arrays of parallel beams of width 500–700 µm. Two irradiation configurations were compared: a lateral unidirectional irradiation and two orthogonal arrays interlacing at the target. A dose escalation study was performed. A factor of three gain in the mean survival time obtained for some animals paves the way for further exploration of the different possibilities of this technique and its further optimization.