Open AccessComparison of in vitro breast cancer visibility in analyser‐based computed tomography with histopathology, mammography, computed tomography and magnetic resonance imaging
Author(s) -
Keyriläinen Jani,
Fernández Manuel,
Bravin Alberto,
KarjalainenLindsberg MarjaLiisa,
Leidenius Marjut,
von Smitten Karl,
Tenhunen Mikko,
Kangasmäki Aki,
Sipilä Petri,
Nemoz Christian,
Virkkunen Pekka,
Suortti Pekka
Publication year - 2011
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s090904951102810x
Subject(s) - mammography , magnetic resonance imaging , breast cancer , computed tomography laser mammography , medicine , histopathology , radiology , nuclear medicine , tomography , computed tomography , cancer , preclinical imaging , pathology , in vivo , microbiology and biotechnology , biology
High‐resolution analyser‐based X‐ray imaging computed tomography (HR ABI‐CT) findings on in vitro human breast cancer are compared with histopathology, mammography, computed tomography (CT) and magnetic resonance imaging. The HR ABI‐CT images provided significantly better low‐contrast visibility compared with the standard radiological images. Fine cancer structures indistinguishable and superimposed in mammograms were seen, and could be matched with the histopathological results. The mean glandular dose was less than 1 mGy in mammography and 12–13 mGy in CT and ABI‐CT. The excellent visibility of in vitro breast cancer suggests that HR ABI‐CT may have a valuable role in the future as an adjunct or even alternative to current breast diagnostics, when radiation dose is further decreased, and compact synchrotron radiation sources become available.