Open AccessSPIO–RGD nanoparticles as a molecular targeting probe for imaging tumor angiogenesis using synchrotron radiation
Author(s) -
Li Jing,
Zhang Chunfu,
Yang Ke,
Liu Ping,
Xu Lisa X.
Publication year - 2011
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s090904951101017x
Subject(s) - synchrotron radiation , angiogenesis , nanoparticle , synchrotron , molecular imaging , materials science , chemistry , nanotechnology , cancer research , medicine , optics , physics , in vivo , biology , microbiology and biotechnology
Angiogenesis, new blood vessels sprouting from pre‐existing vessels, is essential to tumor growth, invasion and metastasis. It can be used as a biomarker for early stage tumor diagnosis and targeted therapy. To visualize angiogenesis many molecular imaging modalities have been used. In this study a novel X‐ray molecular targeting probe using superparamagnetic iron oxide (SPIO) conjugated with arginine–glycine–aspartic acid (SPIO–RGD) has been developed. Based on the extremely high sensitivity to the iron element of synchrotron radiation X‐ray fluorescence and the superior spatial resolution of third‐generation synchrotron radiation, the feasibility of SPIO–RGD as a promising molecular probe for imaging tumor angiogenesis has been demonstrated.