Open AccessImprovement in the quality of hematopoietic prostaglandin D synthase crystals in a microgravity environment
Author(s) -
Tanaka Hiroaki,
Tsurumura Toshiharu,
Aritake Kosuke,
Furubayashi Naoki,
Takahashi Sachiko,
Yamanaka Mari,
Hirota Erika,
Sano Satoshi,
Sato Masaru,
Kobayashi Tomoyuki,
Tanaka Tetsuo,
Inaka Koji,
Urade Yoshihiro
Publication year - 2011
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s0909049510037076
Subject(s) - atp synthase , haematopoiesis , crystallization , enzyme , inflammation , prostaglandin , materials science , chemistry , biophysics , crystallography , biochemistry , microbiology and biotechnology , medicine , biology , immunology , organic chemistry , stem cell
Human hematopoietic prostaglandin synthase, one of the better therapeutic target enzymes for allergy and inflammation, was crystallized with 22 inhibitors and in three inhibitor‐free conditions in microgravity. Most of the space‐grown crystals showed better X‐ray diffraction patterns than the terrestrially grown ones, indicating the advantage of a microgravity environment on protein crystallization, especially in the case of this protein.