Open AccessStructure of the inhibitor complex of old yellow enzyme from Trypanosoma cruzi
Author(s) -
Yamaguchi Keishi,
Okamoto Naoki,
Tokuoka Keiji,
Sugiyama Shigeru,
Uchiyama Nahoko,
Matsumura Hiroyoshi,
Inaka Koji,
Urade Yoshihiro,
Inoue Tsuyoshi
Publication year - 2011
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s0909049510033595
Subject(s) - menadione , oxidoreductase , trypanosoma cruzi , enzyme , biochemistry , stereochemistry , chemistry , flavin group , biology , parasite hosting , world wide web , computer science
Old yellow enzyme (OYE) is an NADPH oxidoreductase which contains flavin mononucleotide as prosthetic group. The X‐ray structures of OYE from Trypanosoma cruzi (TcOYE) which produces prostaglandin (PG) F 2α from PGH 2 have been determined in the presence or absence of menadione. The binding motif of menadione, known as one of the inhibitors for TcOYE, should accelerate the structure‐based development of novel anti‐chagasic drugs that inhibit PGF 2α production specifically.