Open AccessFirst trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy
Author(s) -
Serduc Raphaël,
BräuerKrisch Elke,
Bouchet Audrey,
Renaud Luc,
Brochard Thierry,
Bravin Alberto,
Laissue Jean Albert,
Le Duc Géraldine
Publication year - 2009
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s0909049509012485
Subject(s) - microbeam , synchrotron radiation , radiation therapy , nuclear medicine , synchrotron , irradiation , radiation , x ray , materials science , radiochemistry , medicine , optics , radiology , physics , chemistry , nuclear physics
The technical feasibility of temporal and spatial fractionations of the radiation dose has been evaluated using synchrotron microbeam radiation therapy for brain tumors in rats. A significant increase in lifespan (216%, p < 0.0001) resulted when three fractions of microbeam irradiation were applied to the tumor through three different ports, orthogonal to each other, at 24 h intervals. However, there were no long‐term survivors, and immunohistological studies revealed that 9 L tumors were not entirely ablated.