First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy | Zendy

Serduc Raphaël | Zendy; BräuerKrisch Elke | Zendy; Bouchet Audrey | Zendy; Renaud Luc | Zendy; Brochard Thierry | Zendy; Bravin Alberto | Zendy; Laissue Jean Albert | Zendy; Le Duc Géraldine | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy

Author(s) -

Serduc Raphaël,

BräuerKrisch Elke,

Bouchet Audrey,

Renaud Luc,

Brochard Thierry,

Bravin Alberto,

Laissue Jean Albert,

Le Duc Géraldine

Publication year - 2009

Publication title -

journal of synchrotron radiation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.172

H-Index - 99

ISSN - 1600-5775

DOI - 10.1107/s0909049509012485

Subject(s) - microbeam , synchrotron radiation , radiation therapy , nuclear medicine , synchrotron , irradiation , radiation , x ray , materials science , radiochemistry , medicine , optics , radiology , physics , chemistry , nuclear physics

The technical feasibility of temporal and spatial fractionations of the radiation dose has been evaluated using synchrotron microbeam radiation therapy for brain tumors in rats. A significant increase in lifespan (216%, p < 0.0001) resulted when three fractions of microbeam irradiation were applied to the tumor through three different ports, orthogonal to each other, at 24 h intervals. However, there were no long‐term survivors, and immunohistological studies revealed that 9 L tumors were not entirely ablated.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research