Open AccessX‐ray fluorescent CT imaging of cerebral uptake of stable‐iodine perfusion agent iodoamphetamine analog IMP in mice
Author(s) -
Takeda Tohoru,
Wu Jin,
Huo Qingkai,
Yuasa Tetsuya,
Hyodo Kazuyuki,
Dilmanian F. Avraham,
Akatsuka Takao
Publication year - 2009
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s0909049508031853
Subject(s) - in vivo , ex vivo , cerebral perfusion pressure , hippocampus , perfusion , perfusion scanning , cerebral cortex , fluorescence , preclinical imaging , nuclear medicine , chemistry , medicine , radiology , biology , optics , physics , microbiology and biotechnology
Using X‐ray fluorescent computed tomography (XFCT), the in vivo and ex vivo cerebral distribution of a stable‐iodine‐labeled cerebral perfusion agent, iodoamphetamine analog ( 127 I‐IMP), has been recorded in the brains of mice. In vivo cerebral perfusion in the cortex, hippocampus and thalamus was depicted at 0.5 mm in‐plane spatial resolution. Ex vivo XFCT images at 0.25 mm in‐plane spatial resolution allowed the visualisation of the detailed structures of these regions. The quality of the XFCT image of the hippocampus was comparable with the 125 I‐IMP autoradiogram. These results highlight the sensitivity of XFCT and its considerable potential to evaluate cerebral perfusion in small animals without using radioactive agents.