Open AccessMorphological study of early‐stage lung cancer using synchrotron radiation
Author(s) -
Liu Ping,
Sun Jianqi,
Guan Yijing,
Yue Weisheng,
Xu Lisa X.,
Li Yan,
Zhang Guilin,
Hwu Yeukuang,
Je Jung Ho,
Margaritondo G.
Publication year - 2008
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s0909049507045761
Subject(s) - lung cancer , synchrotron radiation , synchrotron , stage (stratigraphy) , lung , angiogenesis , cancer , medicine , nuclear medicine , pathology , radiology , cancer research , biology , optics , physics , paleontology
In the present study the feasibility of applying synchrotron radiation to the morphological study of early‐stage lung cancer has been investigated. Lewis lung cancer was implanted and grown in a nude mouse for different periods, and imaged using phase‐contrast synchrotron X‐rays. Morphological differences were clearly shown between the normal lung and cancerous tissues at this early stage. Irregular and tortuous angiogenesis were found in the periphery region of the developing lung cancer. Results from this study indicate that synchrotron X‐rays can be used for imaging cancer development and progression with minimal invasion.