Open AccessEXAFS characterization of oxaliplatin anticancer drug and its degradation in chloride media
Author(s) -
Bouvet Diane,
Michalowicz Alain,
CrausteManciet Sylvie,
Curis Emmanuel,
Nicolis Ioannis,
Olivi Luca,
Vlaic Gilberto,
Brossard Denis,
Provost Karine
Publication year - 2006
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s0909049506038283
Subject(s) - extended x ray absorption fine structure , chloride , chemistry , coordination sphere , degradation (telecommunications) , ion , oxaliplatin , inorganic chemistry , absorption spectroscopy , organic chemistry , medicine , telecommunications , physics , colorectal cancer , quantum mechanics , cancer , computer science
Oxaliplatin is a second‐generation platinum‐based anticancer drug. Its degradation is studied in solution, in the presence of chloride ions (in neutral or acidic media) in excess. In both cases the degradation product precipitates immediately. The EXAFS spectra of these products show that they are identical. EXAFS modeling and refinement of the first coordination sphere shows that two light atoms are replaced by two chloride ions. The complete refinement of the local structure is possible by studying the multiple‐scattering signal. The results show that the main multiple‐scattering contribution is due to the binding oxalato group and that the degradation product is [Cl 2 ‐(diaminocyclohexane)‐Pt(II)].