Open AccessXAFS spectroscopy of a single neuron from a patient with Parkinson's disease
Author(s) -
Yoshida Sohei,
Ektessabi Ali,
Fujisawa Shigeyoshi
Publication year - 2001
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s0909049500017726
Subject(s) - substantia nigra , x ray absorption fine structure , xanes , neuromelanin , ferrous , ferric , chemistry , chemical state , neuron , spectroscopy , parkinson's disease , nuclear magnetic resonance , pathology , neuroscience , inorganic chemistry , x ray photoelectron spectroscopy , disease , biology , medicine , organic chemistry , physics , quantum mechanics
Chemical state of transition metals such as iron in a single neuron of the substantia nigra (SN) from a patient with Parkinson's disease (PD) was studied in this paper, using autopsy midbrain specimens including SN. Parkinson's disease is one of the major neurodegenerative diseases. The excessive accumulation of iron and its chemical states in SN neurons are related to the oxidative damage leading to neuronal cell death. X‐ray absorption fine structure spectroscopy (XAFS) with SR micro beam (10 µm) was used to investigate the chemical state of iron in the SN neurons. X‐ray absorption near‐edge structure (XANES) spectroscopy results showed that the chemical state of iron in the neuromelanin granules within SN neurons changed from ferrous (Fe 2+ ) to ferric (Fe 3+ ) ion in the process of neuronal degeneration.