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Application of the molecular replacement method to a heavy‐atom problem
Author(s) -
Arnez John G.
Publication year - 1999
Publication title -
journal of applied crystallography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.429
H-Index - 162
ISSN - 1600-5767
DOI - 10.1107/s002188989900165x
Subject(s) - atom (system on chip) , derivative (finance) , crystal (programming language) , molecular replacement , molecule , chemistry , unit (ring theory) , crystal structure , crystallography , mathematics , computer science , organic chemistry , mathematics education , financial economics , embedded system , economics , programming language
The molecular replacement method has been applied to the heavy‐atom problem in a case for which a heavy‐atom model existed for one crystal form, and both native and derivative data were available for another crystal form of the same molecule; the absolute values of difference amplitudes for the second form were used in the calculation. The key requirement for obtaining a solution is that the contents of the asymmetric unit are the same and the same heavy‐atom compound is used in both cases.