Implementation of a six‐dimensional search using the  AMoRe  translation function for difficult molecular‐replacement problems | Zendy

Sheriff Steven | Zendy; Klei Herbert E. | Zendy; Davis Malcolm E. | Zendy

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Implementation of a six‐dimensional search using the AMoRe translation function for difficult molecular‐replacement problems

Author(s) -

Sheriff Steven,

Klei Herbert E.,

Davis Malcolm E.

Publication year - 1999

Publication title -

journal of applied crystallography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.429

H-Index - 162

ISSN - 1600-5767

DOI - 10.1107/s0021889898010656

Subject(s) - perl , molecular replacement , translation (biology) , yield (engineering) , scripting language , computer science , monomer , function (biology) , set (abstract data type) , chemistry , molecule , materials science , crystallography , combinatorial chemistry , programming language , organic chemistry , polymer , biology , biochemistry , evolutionary biology , messenger rna , gene , metallurgy

A six‐dimensional molecular‐replacement procedure has been implemented using Perl scripts and the CCP 4 version of the translation function of the molecular‐replacement program AMoRe . These tools have allowed the structure determination of CTLA‐4 monomer from NMR‐derived coordinates, and of a potential complex of MurD with a substrate. In both cases other molecular‐replacement programs, X‐PLOR and AMoRe , when used in a conventional manner, either failed or did not yield an obvious solution.

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