Premium
Protein symmetry: metric and crystal (a precautionary note)
Author(s) -
Mighell A. D.,
Rodgers J. R.,
Karen V. L.
Publication year - 1993
Publication title -
journal of applied crystallography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.429
H-Index - 162
ISSN - 1600-5767
DOI - 10.1107/s0021889892008434
Subject(s) - symmetry (geometry) , symmetry operation , metric (unit) , theoretical physics , lattice (music) , symmetry group , crystal structure , group (periodic table) , physics , crystallography , chemistry , quantum mechanics , mathematics , geometry , operations management , acoustics , economics
A review of the symmetry of proteins has revealed that in many cases the metric symmetry exceeds the reported crystal symmetry. Regardless of the reason, this observation has important implications for experimental protein crystallography. Standard laboratory procedure should always include a direct determination of the lattice metric symmetry. With full knowledge of the highest possible symmetry, the experimentalist is then able to determine in a logical and accurate manner the Laue group and the space group. For those proteins in which it has been proved that the metric symmetry exceeds the crystal symmetry, the protein crystallographer must proceed with caution ( e.g. in relating multiple sets of data, positional parameters etc . on the same or related crystals), because a given lattice will have metrically similar unit cells that are not symmetrically equivalent.