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Dose optimization approach to fast X‐ray microtomography of the lung alveoli
Author(s) -
Lovric Goran,
Barré Sébastien F.,
Schittny Johannes C.,
RothKleiner Matthias,
Stampai Marco,
Mokso Rajmund
Publication year - 2013
Publication title -
journal of applied crystallography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.429
H-Index - 162
ISSN - 1600-5767
DOI - 10.1107/s0021889813005591
Subject(s) - radiation dose , x ray microtomography , x ray , in vivo , computer science , radiation , nuclear medicine , materials science , physics , medicine , optics , biology , microbiology and biotechnology
A basic prerequisite for in vivo X‐ray imaging of the lung is the exact determination of radiation dose. Achieving resolutions of the order of micrometres may become particularly challenging owing to increased dose, which in the worst case can be lethal for the imaged animal model. A framework for linking image quality to radiation dose in order to optimize experimental parameters with respect to dose reduction is presented. The approach may find application for current and future in vivo studies to facilitate proper experiment planning and radiation risk assessment on the one hand and exploit imaging capabilities on the other.