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Morphology of polysorbate 80 (Tween 80) micelles in aqueous 1,4‐dioxane solutions
Author(s) -
Aizawa Hideki
Publication year - 2009
Publication title -
journal of applied crystallography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.429
H-Index - 162
ISSN - 1600-5767
DOI - 10.1107/s002188980902295x
Subject(s) - micelle , aqueous solution , pulmonary surfactant , chemistry , solvent , 1,4 dioxane , shell (structure) , chemical engineering , solvation shell , polysorbate , ionic strength , inner core , intermolecular force , molecule , crystallography , organic chemistry , materials science , composite material , solvation , biochemistry , engineering
The structures of micelles of the surfactant polysorbate 80 (Tween 80) in 0–50% aqueous 1,4‐dioxane solutions (pH 7.2, ionic strength 2.44 m M ) were investigated by means of small‐angle X‐ray scattering. At 1,4‐dioxane concentrations of 0–20%, core–shell cylindrical micelles formed because the crown‐shaped polysorbate 80 molecules aggregated into a cylindrical layer of four chains entangled with one another through intra‐ and intermolecular interactions. At 30–40% 1,4‐dioxane, core–shell discus micelles formed, and at 50% 1,4‐dioxane, core–shell elliptic discus micelles formed by the same mechanism. By changing the 1,4‐dioxane solvent concentration and increasing the solvent hydrophobicity, the micelles first change from core–shell cylindrical to core–shell discus and then from core–shell discus to core–shell elliptic discus micelles.