Premium
Synthesis, crystal structure and biological activity of 2‐[2‐(quinolin‐2‐yl)vinyl]‐8‐hydroxyquinoline and 2‐[2‐(quinolin‐4‐yl)vinyl]‐8‐hydroxyquinoline
Author(s) -
Wang TingTing,
Xu DanFeng,
Cai YuePeng,
Chen DongFeng,
Zeng HePing
Publication year - 2007
Publication title -
journal of applied crystallography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.429
H-Index - 162
ISSN - 1600-5767
DOI - 10.1107/s0021889807007704
Subject(s) - 8 hydroxyquinoline , chemistry , monoclinic crystal system , quinoline , hydrogen bond , tetragonal crystal system , crystal structure , bromide , crystallography , stereochemistry , molecule , organic chemistry
Two new isomeric 8‐hydroxyquinoline derivatives with quinoline groups have been synthesized by Perkin condensation. Their structures were characterized by EI‐MS, 1 H NMR spectroscopy, elemental analysis and FT–IR spectroscopy; crystal structures were determined by X‐ray crystallography. 2‐[2‐(Quinolin‐2‐yl)vinyl]‐8‐hydroxyquinoline crystallizes in the tetragonal space group I 4 1 / a and 2‐[2‐(quinolin‐4‐yl)vinyl]‐8‐hydroxyquinoline crystallizes in the monoclinic space group P 2 1 / n . Hydrogen bonds and intermolecular interactions are observed in the compounds and stabilize their structures. The biological activities were investigated by MTT [3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide] assay and flow cytometry analysis, and the results revealed that the two compounds had effects on the proliferation of rat mesenchymal stem cells.