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On the interaction of azithromycin monohydrate with metallic containers
Author(s) -
MontejoBernardo J.,
GarcíaGranda S.,
Llorente I.,
BayodJasanada M.,
Llavona L.
Publication year - 2006
Publication title -
journal of applied crystallography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.429
H-Index - 162
ISSN - 1600-5767
DOI - 10.1107/s0021889806042208
Subject(s) - crystal habit , crystal (programming language) , azithromycin , metal , crystallization , crystallography , molecule , erythromycin , derivative (finance) , materials science , chemistry , antibiotics , organic chemistry , metallurgy , computer science , biochemistry , economics , financial economics , programming language
The monohydrate form of azithromycin (an antibiotic semisynthetic derivative of erythromycin A) is difficult to manipulate due to its great propensity to stick to metallic surfaces (during crystallization, drying, grinding, etc. ). In this paper, this behaviour is explained on the basis of the conformation and packing of the azithromycin molecules in this crystal form. In particular, the crystal habit favours interaction between the N and O atoms with the metal through one particular crystal face.