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An automated platform for parallel crystallization of small organic molecules
Author(s) -
Johnston Andrea,
Fernandes Philippe,
Shankland Norman,
Shankland Kenneth,
Florence Alastair J.
Publication year - 2006
Publication title -
journal of applied crystallography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.429
H-Index - 162
ISSN - 1600-5767
DOI - 10.1107/s0021889806040921
Subject(s) - crystallization , computer science , organic molecules , grid , principal (computer security) , molecule , process engineering , materials science , chemistry , organic chemistry , engineering , mathematics , operating system , geometry
An automated platform for parallel crystallization of small organic molecules from solution is described. The principal gain over manual crystallization lies in the automated sequencing of crystallization steps, including computer‐controlled dosing of liquids and solids. The platform is designed to conduct 32 crystallizations per day, from solution volumes up to 10 ml, allowing a search for physical forms to be conducted over a finer grid than might be accessible manually and thereby increasing the probability of success.