B-BOX DOMAIN PROTEIN28 Negatively Regulates Photomorphogenesis by Repressing the Activity of Transcription Factor HY5 and Undergoes COP1-Mediated Degradation | Zendy

Fang Lin | Zendy; Yan Jiang | Zendy; Jian Li | Zendy; Tingting Yan | Zendy; LiuMin Fan | Zendy; Jiansheng Liang | Zendy; Z. Jeffrey Chen | Zendy; Dongqing Xu | Zendy; Xing Wang Deng | Zendy

Open Access

B-BOX DOMAIN PROTEIN28 Negatively Regulates Photomorphogenesis by Repressing the Activity of Transcription Factor HY5 and Undergoes COP1-Mediated Degradation

Author(s) -

Fang Lin,

Yan Jiang,

Jian Li,

Tingting Yan,

LiuMin Fan,

Jiansheng Liang,

Z. Jeffrey Chen,

Dongqing Xu,

Xing Wang Deng

Publication year - 2018

Publication title -

the plant cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.324

H-Index - 341

eISSN - 1532-298X

pISSN - 1040-4651

DOI - 10.1105/tpc.18.00226

Subject(s) - photomorphogenesis , transcription factor , biology , proteasome , microbiology and biotechnology , arabidopsis , promoter , arabidopsis thaliana , transcription (linguistics) , gene , genetics , mutant , gene expression , linguistics , philosophy

Plants have evolved a delicate molecular system to fine-tune their growth and development in response to dynamically changing light environments. In this study, we found that BBX28, a B-box domain protein, negatively regulates photomorphogenic development in a dose-dependent manner in Arabidopsis thaliana BBX28 interferes with the binding of transcription factor HY5 to the promoters of its target genes through physical interactions, thereby repressing its activity and negatively affecting HY5-regulated gene expression. In darkness, BBX28 associates with CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1) and undergoes COP1-mediated degradation via the 26S proteasome system. Collectively, these results demonstrate that BBX28 acts as a key factor in the COP1-HY5 regulatory hub by maintaining proper HY5 activity to ensure normal photomorphogenic development in plants.

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