A Mitogen-Activated Protein Kinase Cascade Module, MKK3-MPK6 and MYC2, Is Involved in Blue Light-Mediated Seedling Development in Arabidopsis  | Zendy

Vishmita Sethi | Zendy; Raghuram Badmi | Zendy; Alok Sinha | Zendy; Sudip Chattopadhyay | Zendy

Open Access

A Mitogen-Activated Protein Kinase Cascade Module, MKK3-MPK6 and MYC2, Is Involved in Blue Light-Mediated Seedling Development in Arabidopsis

Author(s) -

Vishmita Sethi,

Raghuram Badmi,

Alok Sinha,

Sudip Chattopadhyay

Publication year - 2014

Publication title -

the plant cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.324

H-Index - 341

eISSN - 1532-298X

pISSN - 1040-4651

DOI - 10.1105/tpc.114.128702

Subject(s) - arabidopsis , biology , microbiology and biotechnology , signal transduction , mapk/erk pathway , kinase , transcription factor , protein kinase a , photomorphogenesis , phosphorylation , arabidopsis thaliana , biochemistry , mutant , gene

Mitogen-activated protein kinase (MAPK) pathways are involved in several signal transduction processes in eukaryotes. Light signal transduction pathways have been extensively studied in plants; however, the connection between MAPK and light signaling pathways is currently unknown. Here, we show that MKK3-MPK6 is activated by blue light in a MYC2-dependent manner. MPK6 physically interacts with and phosphorylates a basic helix-loop-helix transcription factor, MYC2, and is phosphorylated by a MAPK kinase, MKK3. Furthermore, MYC2 binds to the MPK6 promoter and regulates its expression in a feedback regulatory mechanism in blue light signaling. We present mutational and physiological studies that illustrate the function of the MKK3-MPK6-MYC2 module in Arabidopsis thaliana seedling development and provide a revised mechanistic view of photomorphogenesis.

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