Marked for Destruction: MANNOSIDASE4 and 5 Process N-Linked Glycans into ER-Associated Degradation Tags | Zendy

Nancy R. Hofmann | Zendy

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Marked for Destruction: MANNOSIDASE4 and 5 Process N-Linked Glycans into ER-Associated Degradation Tags

Author(s) -

Nancy R. Hofmann

Publication year - 2014

Publication title -

the plant cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.324

H-Index - 341

eISSN - 1532-298X

pISSN - 1040-4651

DOI - 10.1105/tpc.114.126870

Subject(s) - endoplasmic reticulum , biology , glycan , chaperone (clinical) , microbiology and biotechnology , protein folding , endoplasmic reticulum associated protein degradation , cell , biochemistry , glycoprotein , unfolded protein response , medicine , pathology

Elaborate chaperone systems in the endoplasmic reticulum (ER) fold nascent polypeptides and refold misfolded proteins, but if those systems fail or get overwhelmed, the resulting aberrant proteins can be harmful and even toxic to the cell. ER quality control is therefore a critical area of cell

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