ThePh1Locus Suppresses Cdk2-Type Activity during Premeiosis and Meiosis in Wheat  | Zendy

Emma Greer | Zendy; Azahara C. Martín | Zendy; Ali Pendle | Zendy; Isabelle Colas | Zendy; Alexandra M. E. Jones | Zendy; Graham Moore | Zendy; Peter Shaw | Zendy

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ThePh1Locus Suppresses Cdk2-Type Activity during Premeiosis and Meiosis in Wheat

Author(s) -

Emma Greer,

Azahara C. Martín,

Ali Pendle,

Isabelle Colas,

Alexandra M. E. Jones,

Graham Moore,

Peter Shaw

Publication year - 2012

Publication title -

the plant cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.324

H-Index - 341

eISSN - 1532-298X

pISSN - 1040-4651

DOI - 10.1105/tpc.111.094771

Subject(s) - biology , homologous chromosome , meiosis , locus (genetics) , genetics , cyclin dependent kinase , cyclin dependent kinase 2 , pairing , synapsis , histone , replication timing , chromosome , gene , microbiology and biotechnology , chromatin , cell cycle , superconductivity , physics , quantum mechanics

Despite possessing multiple sets of related (homoeologous) chromosomes, hexaploid wheat (Triticum aestivum) restricts pairing to just true homologs at meiosis. Deletion of a single major locus, Pairing homoeologous1 (Ph1), allows pairing of homoeologs. How can the same chromosomes be processed as homologs instead of being treated as nonhomologs? Ph1 was recently defined to a cluster of defective cyclin-dependent kinase (Cdk)-like genes showing some similarity to mammalian Cdk2. We reasoned that the cluster might suppress Cdk2-type activity and therefore affect replication and histone H1 phosphorylation. Our study does indeed reveal such effects, suggesting that Cdk2-type phosphorylation has a major role in determining chromosome specificity during meiosis.

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