Form, Function, and Regulation of ARGONAUTE Proteins | Zendy

Allison Mallory | Zendy; Hervé Vaucheret | Zendy

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Form, Function, and Regulation of ARGONAUTE Proteins

Author(s) -

Allison Mallory,

Hervé Vaucheret

Publication year - 2010

Publication title -

the plant cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.324

H-Index - 341

eISSN - 1532-298X

pISSN - 1040-4651

DOI - 10.1105/tpc.110.080671

Subject(s) - argonaute , biology , rasirna , gene silencing , gene , transposable element , genetics , trans acting sirna , rna interference , piwi interacting rna , rna induced silencing complex , computational biology , rna , rna silencing , arabidopsis thaliana , function (biology) , regulation of gene expression , genome , mutant

Both transcriptional (TGS) and posttranscriptional gene silencing (PTGS) are conserved eukaryotic gene regulatory mechanisms, integral for taming exogenous (viruses and bacteria) or endogenous (repetitive elements and transposons) invasive nucleic acids to minimize their impact on genome integrity and function. TGS and PTGS also are essential for controlling the expression of protein coding genes throughout development or in response to environmental stimuli. In plants and animals, at least one member of the conserved ARGONAUTE (AGO) protein family comprises the catalytic engine of the silencing complex, which is guided by sequence-specific small RNA to cognate RNA. In this review, we present general features of plant and animal AGO proteins and detail our knowledge on the 10 Arabidopsis thaliana AGOs.

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