Evidence for a Direct Link between Glutathione Biosynthesis and Stress Defense Gene Expression in Arabidopsis[W] | Zendy

Louise M. Ball | Zendy; Gian Paolo Accotto | Zendy; Ulrike Bechtold | Zendy; Gary Creissen | Zendy; Dietmar Funck | Zendy; Ana Jiménez | Zendy; Baldeep Kular | Zendy; Nicola Leyland | Zendy; Jaime Mejía-Carranza | Zendy; Helen Reynolds | Zendy; Stanisław Karpiński | Zendy; Philip M. Mullineaux | Zendy

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Evidence for a Direct Link between Glutathione Biosynthesis and Stress Defense Gene Expression in Arabidopsis[W]

Author(s) -

Louise M. Ball,

Gian Paolo Accotto,

Ulrike Bechtold,

Gary Creissen,

Dietmar Funck,

Ana Jiménez,

Baldeep Kular,

Nicola Leyland,

Jaime Mejía-Carranza,

Helen Reynolds,

Stanisław Karpiński,

Philip M. Mullineaux

Publication year - 2004

Publication title -

the plant cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.324

H-Index - 341

eISSN - 1532-298X

pISSN - 1040-4651

DOI - 10.1105/tpc.104.022608

Subject(s) - biology , glutathione , arabidopsis , mutant , arabidopsis thaliana , glutathione synthetase , biochemistry , gene , gene expression , microbiology and biotechnology , biosynthesis , regulation of gene expression , genetics , enzyme

The mutant regulator of APX2 1-1 (rax1-1) was identified in Arabidopsis thaliana that constitutively expressed normally photooxidative stress-inducible ASCORBATE PEROXIDASE2 (APX2) and had >/=50% lowered foliar glutathione levels. Mapping revealed that rax1-1 is an allele of gamma-GLUTAMYLCYSTEINE SYNTHETASE 1 (GSH1), which encodes chloroplastic gamma-glutamylcysteine synthetase, the controlling step of glutathione biosynthesis. By comparison of rax1-1 with the GSH1 mutant cadmium hypersensitive 2, the expression of 32 stress-responsive genes was shown to be responsive to changed glutathione metabolism. Under photo-oxidative stress conditions, the expression of a wider set of defense-related genes was altered in the mutants. In wild-type plants, glutathione metabolism may play a key role in determining the degree of expression of defense genes controlled by several signaling pathways both before and during stress. This control may reflect the physiological state of the plant at the time of the onset of an environmental challenge and suggests that changes in glutathione metabolism may be one means of integrating the function of several signaling pathways.

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