A Novel Class of Herbicides (Specific Inhibitors of Imidazoleglycerol Phosphate Dehydratase) | Zendy

Ichiro Mori | Zendy; R. Fonne-Pfister | Zendy; Si. Matsunaga | Zendy; S. Tada | Zendy; Yoko Kimura | Zendy; Genji Iwasaki | Zendy; Jun’ichi Mano | Zendy; Manabu Hatano | Zendy; Toshihito Nakano | Zendy; Si. Koizumi | Zendy; Alfred Scheidegger | Zendy; K. HAYAKAWA | Zendy; Daisaku Ohta | Zendy

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A Novel Class of Herbicides (Specific Inhibitors of Imidazoleglycerol Phosphate Dehydratase)

Author(s) -

Ichiro Mori,

R. Fonne-Pfister,

Si. Matsunaga,

S. Tada,

Yoko Kimura,

Genji Iwasaki,

Jun’ichi Mano,

Manabu Hatano,

Toshihito Nakano,

Si. Koizumi,

Alfred Scheidegger,

K. HAYAKAWA,

Daisaku Ohta

Publication year - 1995

Publication title -

plant physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.554

H-Index - 312

eISSN - 1532-2548

pISSN - 0032-0889

DOI - 10.1104/pp.107.3.719

Subject(s) - dehydratase , enzyme , biosynthesis , chemistry , phosphate , histidine , cytotoxicity , biochemistry , stereochemistry , cytotoxic t cell , enzyme inhibition , in vitro

A new mode of herbicidal action was established by finding specific inhibitors of imidazoleglycerol phosphate dehydratase, an enzyme of histidine (His) biosynthesis. Three triazole phosphonates inhibited the reaction of the enzyme with Ki values of 40 [plus or minus] 6.5, 10 [plus or minus] 1.6, and 8.5 [plus or minus] 1.4 nM, respectively, and were highly cytotoxic to cultured plant cells. This effect was completely reversed by the addition of His, proving that the cytotoxicity was primarily caused by the inhibition of His biosynthesis. These inhibitors showed wide-spectrum, postemergent herbicidal activity at application rates ranging from 0.05 to 2 kg/ha.

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