Open AccessLifelong reductions of PKMζ in ventral hippocampus of nonhuman primates exposed to early-life adversity due to unpredictable maternal care
Author(s) -
Sasha L. Fulton,
Changchi Hsieh,
Tobias Atkin,
R. P. Norris,
Eric M. Schoenfeld,
Panayiotis Tsokas,
André A. Fenton,
Todd Sacktor,
Jeremy D. Coplan
Publication year - 2021
Publication title -
learning and memory
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.228
H-Index - 136
eISSN - 1549-5485
pISSN - 1072-0502
DOI - 10.1101/lm.053468.121
Subject(s) - dentate gyrus , psychology , hippocampus , long term potentiation , neuroscience , anxiety , mood , prefrontal cortex , subiculum , developmental psychology , cognition , clinical psychology , medicine , psychiatry , receptor
Protein kinase Mζ (PKMζ) maintains long-term potentiation (LTP) and long-term memory through persistent increases in kinase expression. Early-life adversity is a precursor to adult mood and anxiety disorders, in part, through persistent disruption of emotional memory throughout life. Here we subjected 10- to 16-wk-old male bonnet macaques to adversity by a maternal variable-foraging demand paradigm. We then examined PKMζ expression in their ventral hippocampi as 7- to 12-yr-old adults. Quantitative immunohistochemistry reveals decreased PKMζ in dentate gyrus, CA1, and subiculum of subjects who had experienced early-life adversity due to the unpredictability of maternal care. Adult animals with persistent decrements of PKMζ in ventral hippocampus express timid rather than confrontational responses to a human intruder. Persistent down-regulation of PKMζ in the ventral hippocampus might reduce the capacity for emotional memory maintenance and contribute to the long-lasting emotional effects of early-life adversity.