A Stem Cell Approach to Cure Type 1 Diabetes | Zendy

Aharon Helman | Zendy; Douglas A. Melton | Zendy

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A Stem Cell Approach to Cure Type 1 Diabetes

Author(s) -

Aharon Helman,

Douglas A. Melton

Publication year - 2020

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a035741

Subject(s) - biology , induced pluripotent stem cell , stem cell , type 2 diabetes , islet , type 1 diabetes , diabetes mellitus , immune system , pancreas , disease , cell type , immunology , bioinformatics , microbiology and biotechnology , cell , medicine , embryonic stem cell , endocrinology , genetics , gene

Treatment of type 1 diabetes with insulin injection is expensive, complicated, and insufficient. While cadaveric islet transplantations coupled with immunosuppressants can cure diabetes, the scarcity of acceptable islets is problematic. Developmental research on pancreas formation has informed in vitro differentiation of human pluripotent stem cells into functional islets. Although generating β cells from stem cells offers a potential cure for type 1 diabetes, several challenges remain, including protecting the cells from the immune system.

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