Signaling through Ca2+Microdomains from Store-Operated CRAC Channels | Zendy

Pradeep Barak | Zendy; Anant B. Parekh | Zendy

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Signaling through Ca²⁺Microdomains from Store-Operated CRAC Channels

Author(s) -

Pradeep Barak,

Anant B. Parekh

Publication year - 2019

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a035097

Subject(s) - lipid microdomain , biology , calcium signaling , calcium , microbiology and biotechnology , orai1 , biophysics , signal transduction , membrane , biochemistry , stim1 , chemistry , endoplasmic reticulum , organic chemistry

Calcium (Ca 2+ ) ion microdomains are subcellular regions of high Ca 2+ concentration that develop rapidly near open Ca 2+ channels in the plasma membrane or internal stores and generate local regions of high Ca 2+ concentration. These microdomains are remarkably versatile in that they activate a range of responses that differ enormously in both their temporal and spatial profile. In this review, we describe how Ca 2+ microdomains generated by store-operated calcium channels, a widespread and conserved Ca 2+ entry pathway, stimulate different signaling pathways, and how the spatial extent of a Ca 2+ microdomain can be influenced by Ca 2+ ATPase pumps.

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