Open AccessMechanistic Insights into MicroRNA-Mediated Gene Silencing
Author(s) -
Thomas F. Duchaîne,
Marc R. Fabian
Publication year - 2018
Publication title -
cold spring harbor perspectives in biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.011
H-Index - 173
ISSN - 1943-0264
DOI - 10.1101/cshperspect.a032771
Subject(s) - biology , gene silencing , library science , microrna , gene , genetics , computer science
MicroRNAs (miRNAs) posttranscriptionally regulate gene expression by repressing protein synthesis and exert a broad influence over development, physiology, adaptation, and disease. Over the past two decades, great strides have been made toward elucidating how miRNAs go about shutting down messenger RNA (mRNA) translation and promoting mRNA decay.
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