The Epitranscriptome in Translation Regulation | Zendy

Eyal Peer | Zendy; Sharon Moshitch-Moshkovitz | Zendy; Gideon Rechavi | Zendy; Dan Dominissini | Zendy

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The Epitranscriptome in Translation Regulation

Author(s) -

Eyal Peer,

Sharon Moshitch-Moshkovitz,

Gideon Rechavi,

Dan Dominissini

Publication year - 2018

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a032623

Subject(s) - biology , translation (biology) , computational biology , evolutionary biology , zoology , genetics , messenger rna , gene

The cellular proteome reflects the total outcome of many regulatory mechanisms that affect the metabolism of messenger RNA (mRNA) along its pathway from synthesis to degradation. Accumulating evidence in recent years has uncovered the roles of a growing number of mRNA modifications in every step along this pathway, shaping translational output. mRNA modifications affect the translation machinery directly, by influencing translation initiation, elongation and termination, or by altering mRNA levels and subcellular localization. Features of modification-related translational control are described, charting a new and complex layer of translational regulation.

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