Hold Me, but Not Too Tight—Endothelial Cell–Cell Junctions in Angiogenesis | Zendy

Anna Szymborska | Zendy; Holger Gerhardt | Zendy

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Hold Me, but Not Too Tight—Endothelial Cell–Cell Junctions in Angiogenesis

Author(s) -

Anna Szymborska,

Holger Gerhardt

Publication year - 2017

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a029223

Subject(s) - biology , angiogenesis , microbiology and biotechnology , sprouting angiogenesis , endothelial stem cell , cell adhesion , context (archaeology) , cell , tight junction , neuroscience , neovascularization , cancer research , genetics , in vitro , paleontology

Endothelial cell-cell junctions must perform seemingly incompatible tasks during vascular development-providing stable connections that prevent leakage, while allowing dynamic cellular rearrangements during sprouting, anastomosis, lumen formation, and functional remodeling of the vascular network. This review aims to highlight recent insights into the molecular mechanisms governing endothelial cell-cell adhesion in the context of vascular development.

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