Cell Junctions in Hippo Signaling | Zendy

Ruçhan Karaman | Zendy; Georg Halder | Zendy

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Cell Junctions in Hippo Signaling

Author(s) -

Ruçhan Karaman,

Georg Halder

Publication year - 2017

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a028753

Subject(s) - hippo signaling pathway , biology , microbiology and biotechnology , signal transduction , regulator , cell growth , cell signaling , cell , genetics , gene

The Hippo signal transduction pathway is an important regulator of organ growth and cell differentiation, and its deregulation contributes to the development of cancer. The activity of the Hippo pathway is strongly dependent on cell junctions, cellular architecture, and the mechanical properties of the microenvironment. In this review, we discuss recent advances in our understanding of how cell junctions transduce signals from the microenvironment and control the activity of the Hippo pathway. We also discuss how these mechanisms may control organ growth during development and regeneration, and how defects in them deregulate Hippo signaling in cancer cells.

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