Mechanisms of Cell Polarity–Controlled Epithelial Homeostasis and Immunity in the Intestine | Zendy

Leon J. Klunder | Zendy; Klaas Nico Faber | Zendy; Gerard Dijkstra | Zendy; Sven C.D. van IJzendoorn | Zendy

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Mechanisms of Cell Polarity–Controlled Epithelial Homeostasis and Immunity in the Intestine

Author(s) -

Leon J. Klunder,

Klaas Nico Faber,

Gerard Dijkstra,

Sven C.D. van IJzendoorn

Publication year - 2017

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a027888

Subject(s) - biology , homeostasis , microbiology and biotechnology , immunity , immune system , polarity (international relations) , cell polarity , epithelial polarity , small intestine , epithelium , cell , gastrointestinal tract , immunology , biochemistry , genetics

Intestinal epithelial cell polarity is instrumental to maintain epithelial homeostasis and balance communications between the gut lumen and bodily tissue, thereby controlling the defense against gastrointestinal pathogens and maintenance of immune tolerance to commensal bacteria. In this review, we highlight recent advances with regard to the molecular mechanisms of cell polarity-controlled epithelial homeostasis and immunity in the human intestine.

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