Detection and Phenotypic Characterization of Adult Neurogenesis | Zendy

H. Georg Kuhn | Zendy; Amelia J. Eisch | Zendy; Kirsty L. Spalding | Zendy; Daniel A. Peterson | Zendy

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Detection and Phenotypic Characterization of Adult Neurogenesis

Author(s) -

H. Georg Kuhn,

Amelia J. Eisch,

Kirsty L. Spalding,

Daniel A. Peterson

Publication year - 2016

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a025981

Subject(s) - biology , neurogenesis , regenerative medicine , library science , neuroscience , gerontology , cognitive science , stem cell , psychology , medicine , genetics , computer science

Studies of adult neurogenesis have greatly expanded in the last decade, largely as a result of improved tools for detecting and quantifying neurogenesis. In this review, we summarize and critically evaluate detection methods for neurogenesis in mammalian and human brain tissue. Besides thymidine analog labeling, cell-cycle markers are discussed, as well as cell stage and lineage commitment markers. Use of these histological tools is critically evaluated in terms of their strengths and limitations, as well as possible artifacts. Finally, we discuss the method of radiocarbon dating for determining cell and tissue turnover in humans.

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