At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code | Zendy

Han Xiao | Zendy; Peter G. Schultz | Zendy

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At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code

Author(s) -

Han Xiao,

Peter G. Schultz

Publication year - 2016

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a023945

Subject(s) - biology , genetic code , computational biology , chemical biology , synthetic biology , function (biology) , amino acid , frameshift mutation , nonsense , genetics , mutation , gene

The ability to site-specifically incorporate noncanonical amino acids (ncAAs) with novel structures into proteins in living cells affords a powerful tool to investigate and manipulate protein structure and function. More than 200 ncAAs with diverse biological, chemical, and physical properties have been genetically encoded in response to nonsense or frameshift codons in both prokaryotic and eukaryotic organisms with high fidelity and efficiency. In this review, recent advances in the technology and its application to problems in protein biochemistry, cellular biology, and medicine are highlighted.

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