TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology | Zendy

Masato Morikawa | Zendy; Rik Derynck | Zendy; Kohei Miyazono | Zendy

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TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology

Author(s) -

Masato Morikawa,

Rik Derynck,

Kohei Miyazono

Publication year - 2016

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a021873

Subject(s) - biology , transforming growth factor , context (archaeology) , microbiology and biotechnology , physiology , paleontology

The transforming growth factor-β (TGF-β) is the prototype of the TGF-β family of growth and differentiation factors, which is encoded by 33 genes in mammals and comprises homo- and heterodimers. This review introduces the reader to the TGF-β family with its complexity of names and biological activities. It also introduces TGF-β as the best-studied factor among the TGF-β family proteins, with its diversity of roles in the control of cell proliferation and differentiation, wound healing and immune system, and its key roles in pathology, for example, skeletal diseases, fibrosis, and cancer.

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