The Nodes of Ranvier: Molecular Assembly and Maintenance | Zendy

Matthew N. Rasband | Zendy; Elior Peles | Zendy

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The Nodes of Ranvier: Molecular Assembly and Maintenance

Author(s) -

Matthew N. Rasband,

Elior Peles

Publication year - 2015

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a020495

Subject(s) - biology , node of ranvier , neuroscience , peripheral nervous system , nervous system , sodium channel , axon , myelin sheath , action potential , central nervous system , anatomy , myelin , electrophysiology , sodium , chemistry , organic chemistry

Action potential (AP) propagation in myelinated nerves requires clustered voltage gated sodium and potassium channels. These channels must be specifically localized to nodes of Ranvier where the AP is regenerated. Several mechanisms have evolved to facilitate and ensure the correct assembly and stabilization of these essential axonal domains. This review highlights the current understanding of the axon intrinsic and glial extrinsic mechanisms that control the formation and maintenance of the nodes of Ranvier in both the peripheral nervous system (PNS) and central nervous system (CNS).

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