Induced Pluripotency and Epigenetic Reprogramming | Zendy

Konrad Hochedlinger | Zendy; Rudolf Jaenisch | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Induced Pluripotency and Epigenetic Reprogramming

Author(s) -

Konrad Hochedlinger,

Rudolf Jaenisch

Publication year - 2015

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a019448

Subject(s) - biology , reprogramming , medical school , stem cell biology , epigenetics , library science , genetics , medicine , computer science , cell , medical education , embryo , gene , reproductive technology , embryogenesis

Induced pluripotency defines the process by which somatic cells are converted into induced pluripotent stem cells (iPSCs) upon overexpression of a small set of transcription factors. In this article, we put transcription factor-induced pluripotency into a historical context, review current methods to generate iPSCs, and discuss mechanistic insights that have been gained into the process of reprogramming. In addition, we focus on potential therapeutic applications of induced pluripotency and emerging technologies to efficiently engineer the genomes of human pluripotent cells for scientific and therapeutic purposes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research