Transcriptional Silencing by Polycomb-Group Proteins | Zendy

Ueli Grossniklaus | Zendy; Renato Paro | Zendy

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Transcriptional Silencing by Polycomb-Group Proteins

Author(s) -

Ueli Grossniklaus,

Renato Paro

Publication year - 2014

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a019331

Subject(s) - biology , polycomb group proteins , gene silencing , group (periodic table) , microbiology and biotechnology , dna binding protein , genetics , transcription factor , gene , repressor , chemistry , organic chemistry

Polycomb-group (PcG) genes encode chromatin proteins involved in stable and heritable transcriptional silencing. PcG proteins participate in distinct multimeric complexes that deposit, or bind to, specific histone modifications (e.g., H3K27me3 and H2AK119ub1) to prevent gene activation and maintain repressed chromatin domains. PcG proteins are evolutionary conserved and play a role in processes ranging from vernalization and seed development in plants, over X-chromosome inactivation in mammals, to the maintenance of stem cell identity. PcG silencing is medically relevant as it is often observed in human disorders, including cancer, and tissue regeneration, which involve the reprogramming of PcG-controlled target genes

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